Biomarkers of acute kidney injury:Pathogenic mechanism and potential therapeutic significance / 医学研究生学报

ABSTRACT

Acute kidney injury ( AKI) is very common clinical syndrome , which may bring worse outcomes and heavy eco-nomic burden .For nearly one and half centuries , the AKI definition and diagnostic criteria have been continuously evaluating and the diagnostic biomarkers of AKI have been constantly emerging with the development of medicine , which make early diagnosis and early intervention of AKI possible .This review highlights the major studies that the diagnostic and prognostic predictive power of neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, IL-18, livertypefatty acid-binding protein, tissue inhibitor of etalloproteinase-2, and IGF-binding protein 7.The mechanistic relevance of these biomarkers to the pathogenesis and pathobiology of AKI is reviewed in this paper , in order to make an early diagnosis and early treatment for AKI and also improve the prognosis of AKI .