Abnormal activation of Notch1 and T-cell acute lymphoblastic leukemia / 临床儿科杂志
Journal of Clinical Pediatrics
;
(12): 483-485, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-461775
ABSTRACT
Abnormal activation of Notch1 plays pivotal roles in the molecular pathogenesis of human T-cell acutelymphoblastic leukemia (T-ALL). Activating Notch1 mutations present in over 60% of the T-ALL patients. However, so far,there is no therapy with little side effects that specifically targets the abnormally activated Notch1 pathway-induced T-ALL. Thepresent study briefly reviewed the effects of abnormal activation of Notch1 in the pathogenesis of T-ALL, as well as the currentapproaches targeting Notch1 and its limitations, thus providing some guidance for the research and development of clinicaltherapies targeting T-ALL.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Guía de Práctica Clínica
Idioma:
Chino
Revista:
Journal of Clinical Pediatrics
Año:
2015
Tipo del documento:
Artículo
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