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A Case of Propylthiouracil Induced Anti: Neutrophil Cytoplasmic Antibody (ANCA) Positive Vasculitis / 대한내분비학회지
Journal of Korean Society of Endocrinology ; : 757-763, 1999.
Artículo en Coreano | WPRIM | ID: wpr-46203
ABSTRACT
A 40-year-old woman just had started to take propylthiouracil for Graves disease, However, the treatment had to be interrupted because she developed skin rash, arthritis, chest pain, fever and proteinuria after 2 months. The serologic study revealed antineutrophil cytoplasmic antibody(ANCA) positivity, especially showing perinuclear pattern. The anti-myeloperoxidase titer was high. The hematoxylin & eosin stain of the specimen obtained from kidney was compatible with pauci-immune glomerulonephritis with crescent formation. There were no immune complex deposits under electron microscope. Such findings suggested propylthiouracil-induced vasculitis. Vasculitis is a rare side effect of propylthiouracil. Recently more cases of vasculitis associated with anti-thyroid drug with ANCA positivity are being reported up to about 36 cases worldwide. There are possibilities of underdiagnosis of this side effect, meaning more cautions on the patients under anti-thyroid drug treatment. We present a case with review of related literature.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Artritis / Propiltiouracilo / Proteinuria / Vasculitis / Dolor en el Pecho / Enfermedad de Graves / Eosina Amarillenta-(YS) / Anticuerpos Anticitoplasma de Neutrófilos / Citoplasma / Exantema Límite: Adulto / Femenino / Humanos Idioma: Coreano Revista: Journal of Korean Society of Endocrinology Año: 1999 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Artritis / Propiltiouracilo / Proteinuria / Vasculitis / Dolor en el Pecho / Enfermedad de Graves / Eosina Amarillenta-(YS) / Anticuerpos Anticitoplasma de Neutrófilos / Citoplasma / Exantema Límite: Adulto / Femenino / Humanos Idioma: Coreano Revista: Journal of Korean Society of Endocrinology Año: 1999 Tipo del documento: Artículo