Effect of Atorvastatin on Plasma MicroRNA-143/145 Expression in Patients With Stable Angina Pectoris / 中国循环杂志

ABSTRACT

Objective: To investigate the effect of atorvastatin on plasma microRNA-143/145 expression in patients with stable angina pectoris (SAP). Methods: A total of 74 SAP patients taken atorvastatin at ifrst time were enrolled in this study, the patients were assigned into 2 groups by the dose of medicationLow dose group, the patients received atorvastatin 20 mg/day, n=36 and Moderate dose group, the patients received atorvastatin 40 mg/day, n=38. Plasma levels of LDL-C and microRNA-143/145 were examined before medication and at 1 month, 12 months after medication respectively. The patients were further divided into another 2 groups by plasma levels of LDL-CReach the standard group, plasma LDL-C Results: ① Compared with baseline condition, plasma levels of microRNA-143/145 were increased in both groups after medication, P0.05. Conclusion: Atorvastatin could up-regulate plasma microRNA-143/145 expression, which was not related to lipid-decreasing effect.