Dexmedetomidine dose for epidural anesthesia in the elderly knee arthroplasty / 中国组织工程研究

ABSTRACT

BACKGROUND:Dural elderly knee arthroplasty anesthesia is a common mode of anesthesia. Dexmedetomidine, because of good analgesic effects, is widely applied to epidural anesthesia in elderly knee replacement, but different applied dose of dexmedetomidine may lead to different results. OBJECTIVE:To explore the effects of different doses of dexmedetomidine for epidural anesthesia in elderly knee arthroplasty. METHODS:A total of 75 cases of older patients undergoing knee replacement surgery were selected and randomly divided into dexmedetomidine loading and maintenance group (25 cases), dexmedetomidine group (25 cases), and the normal saline group (25 cases), and then they were given smal doses of dexmedetomidine loading and maintenance, dexmedetomidine maintenance, intravenous infusion of normal saline. Blood pressure, heart rate, Calm/Alert Standard Score and the operation degree of forgetting were observed and compared in the three groups. The time points included T0 (after epidural anesthesia), T1 (3 minutes after medication), T2 (5 minutes after medication), T3 (10 minutes after medication), T4 (15 minutes after medication), and T5 (30 minutes after medication). RESULTS AND CONCLUSION:After the use of drugs, blood pressure and heart rate were decreased in the dexmedetomidine loading and maintenance group and dexmedetomidine group. Blood pressure and heart rate were significantly lower in the dexmedetomidine loading and maintenance group than that of dexmedetomidine maintenance group (P 0.05). These findings suggest that in elderly patients undergoing knee replacement, smal dose of dexmedetomidine continuous infusion for epidural anesthesia can achieve good effects on analgesia and sedation, can eliminate the bad memories for patients with operation, and is a scientific mode of anesthesia.