Influence of PCI on levels of brain natriuretic peptide and aldosterone and short-term prognosis in patients with acute myocardial infarction / 心血管康复医学杂志

ABSTRACT

Objective:To explore the influence of percutaneous coronary intervention (PCI) on plasma levels of brain natri‐uretic peptide (BNP) and aldosterone (Ald) and short‐term prognosis in patients with acute left ventricular inferior and an‐terior wall myocardial infarction .Methods:A total of 212 patients were divided into acute inferior myocardial infarction (AIMI) group (n=140) and acute anterior myocardial infarction (AAMI) group (n=72) .Relationship among plasma lev‐els of BNP and Ald and coronary artery disease were analyzed in two groups .Changes of plasma levels of BNP and Ald after direct/delayed PCI and influence of PCI on short‐term prognosis were compared between two groups .Results:Compared with AIMI group before PCI ,there were significant rise in plasma levels of BNP [ (642.06 ± 235.08) ng/L vs .(856.54 ± 223.50) ng/L] and Ald [(50.26 ± 5.23) ng/dl vs .(88.34 ± 8.52) ng/dl] ,extent of coronary stenosis [(82.28 ± 7.65)%vs .(90.64 ± 7.54)% ] and incidence rate of triple‐vessel coronary disease (22.52% vs .39.66% ) in AAMI group , P<0.05 all;plasma levels of BNP and Ald significantly reduced in both groups after direct /delayed PCI (P<0.01 both) ,com‐pared with delayed PCI group ,there were significant reductions in plasma levels of BNP [AIMI group(453.75 ± 107.54) ng/L vs .(216.93 ± 119.86) ng/L ,AAMI group(483.04 ± 164.65) ng/L vs .(245.754 ± 121.52) ng/L] and Ald [AIMI group(45.34 ± 8.15) ng/dl vs .(40.09 ± 6.55) ng/dl ,AAMI group(50.43 ± 9.21) ng/dl vs .(43.65 ± 3.50) ng/dl] in direct PCI group , P<0.01 all;short‐term mortality rate of patients not undergoing PCI was significantly higher than those of patients undergoing direct PCI and delayed PCI (11.63% vs .2.78% vs .3.28% , P<0.05 both ) .Conclusion:Plasma levels of BNP and Ald are higher and coronary disease is more severe in AAMI patients ;compared with delayed PCI ,plas‐ma concentrations of BNP and Ald possess higher decreasing extent after undergoing direct PCI ;patients not receiving PCI possess higher mortality rate .