The early diagnostic value of soluble triggering receptor expressed on myeloid cell-1 in patients with sepsis / 国际检验医学杂志

ABSTRACT

Objective To investigate the early diagnostic value of soluble triggering receptor expressed on myeloid cells‐1 (sTREM‐1) in patients with sepsis .Methods Eighty‐one patients between July 2010 and June 2013 were collected .Sixty one pa‐tients with systemic inflammatory response syndrome (SIRS) were divided into sepsis group (n=39) and SIRS group (n=22) ,and the other 20 patients without SIRS were as control group .Levels of sTREM‐1 and procalcitonin (PCT ) were measured .Results The levels of sTREM‐1 and PCT were significant higher in sepsis group and SIRS group than those in control group (P<0 .01) , and the levels of sTREM‐1 and PCT in sepsis group were significant higher than those in SIRS group (P<0 .01) .The area under the curve (AUC) of sTREM‐1 and PCT were 0 .932 and 0 .670 ,respectively .The sensibility and specificity of sTREM‐1 were 92 .3% and 86 .4% ,while the sensibility and specificity of PCT were 61 .5% and 81 .8% .Conclusion Serum sTREM‐1 might be a good biomarker for the early diagnosis of sepsis ,and it has higher sensitivity and specificity in compassion with PCT .