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Antidepressant Use and Diabetes Mellitus Risk: A Meta-Analysis / 가정의학회지
Korean Journal of Family Medicine ; : 228-240, 2013.
Artículo en Inglés | WPRIM | ID: wpr-46495
ABSTRACT

BACKGROUND:

Epidemiologic studies have reported inconsistent findings regarding the association between the use of antidepressants and type 2 diabetes mellitus (DM) risk. We performed a meta-analysis to systematically assess the association between antidepressants and type 2 DM risk.

METHODS:

We searched MEDLINE (PubMed), EMBASE, and the Cochrane Library (through Dec 31, 2011), including references of qualifying articles. Studies concerning the use of tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), or other antidepressants and the associated risk of diabetes mellitus were included.

RESULTS:

Out of 2,934 screened articles, 3 case-control studies, 9 cohort studies, and no clinical trials were included in the final analyses. When all studies were pooled, use of antidepressants was significantly associated with an increased risk of DM in a random effect model (relative risk [RR], 1.49; 95% confidence interval [CI], 1.29 to 1.71). In subgroup analyses, the risk of DM increased among both SSRI users (RR, 1.35; 95% CI, 1.15 to 1.58) and TCA users (RR, 1.57; 95% CI, 1.26 to 1.96). The subgroup analyses were consistent with overall results regardless of study type, information source, country, duration of medication, or study quality. The subgroup results considering body weight, depression severity, and physical activity also showed a positive association (RR, 1.14; 95% CI, 1.01 to 1.28). A publication bias was observed in the selected studies (Egger's test, P for bias = 0.09).

CONCLUSION:

Our results suggest that the use of antidepressants is associated with an increased risk of DM.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Peso Corporal / Serotonina / Norepinefrina / Sesgo / Estudios de Casos y Controles / Estudios de Cohortes / Inhibidores Selectivos de la Recaptación de Serotonina / Sesgo de Publicación / Depresión / Diabetes Mellitus Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo / Revisiones Sistemáticas Evaluadas Idioma: Inglés Revista: Korean Journal of Family Medicine Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Peso Corporal / Serotonina / Norepinefrina / Sesgo / Estudios de Casos y Controles / Estudios de Cohortes / Inhibidores Selectivos de la Recaptación de Serotonina / Sesgo de Publicación / Depresión / Diabetes Mellitus Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo / Revisiones Sistemáticas Evaluadas Idioma: Inglés Revista: Korean Journal of Family Medicine Año: 2013 Tipo del documento: Artículo