Carbohydrate-Deficient Transferrin as a Biomarker for Screening At-Risk Drinking in Elderly Men / 가정의학회지
Korean Journal of Family Medicine
;
: 291-295, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-46521
ABSTRACT
BACKGROUND:
Carbohydrate-deficient transferrin (CDT) is a useful biomarker to identify excessive alcohol consumption; however, few studies have validated the %CDT cut-off value in elderly men. This study estimated the optimal %CDT cut-off value that could identify excessive alcohol consumption in men aged ≥65 years.METHODS:
This retrospective study included 120 men who visited the department of family medicine at Chungnam National University Hospital for health check-up between January 2010 and August 2013. At-risk drinking included heavy- and binge drinking. Heavy drinking was defined as more than seven standard drinks/wk, and binge drinking was defined as more than three standard drinks/d. The cut-off %CDT values for at-risk drinking were determined using receiver operating characteristic (ROC) curves.RESULTS:
Based on the ROC curves, the optimal %CDT cut-off values in ≥65-year-old men were 1.95% for at-risk drinking, 1.81% for heavy drinking, and 2.07% for binge drinking. The sensitivity, specificity, and positive and negative predictive values were 58.7%, 83.6%, 69.2%, and 76.2% for at-risk drinking, respectively. The AUROC were >0.7 for all three evaluated cut-offs.CONCLUSION:
Our results suggest that the %CDT cut-off value for at-risk drinking in elderly Korean men (≥65 years) should be readjusted to a lower value of 1.95%.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Consumo de Bebidas Alcohólicas
/
Transferrina
/
Biomarcadores
/
Tamizaje Masivo
/
Estudios Retrospectivos
/
Curva ROC
/
Sensibilidad y Especificidad
/
Ingestión de Líquidos
/
Consumo Excesivo de Bebidas Alcohólicas
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Anciano
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Korean Journal of Family Medicine
Año:
2017
Tipo del documento:
Artículo
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