Poly (ADP-ribose) polymerase-1 and ischemic brain injury / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
; (12): 946-949, 2014.
Article
en Zh
| WPRIM
| ID: wpr-466516
Biblioteca responsable:
WPRO
ABSTRACT
Poly (ADP-ribose) polymerase-1 (PARP-1) is a ribozyme that widely exists in the cukaryotic cells.It plays important roles in the maintenance of genomic stability and the regulation of gene transcription and other physiological processes.PARP-1 is overactivated after ischemic brain injury,and PARP-1 gene knockout mice or PARP-1 inhibitor can reduce brain injury in a variety of models of cerebral ischemia.Therefore,PARP-1 plays important roles in the pathophysiologic processes of ischemic brain injury.The investigation of the effect of PARP-1 in cerebral ischemia contributes to further understanding the pathophysiologic mechanism of stroke and finding a new therapeutic target.
Texto completo:
1
Índice:
WPRIM
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
International Journal of Cerebrovascular Diseases
Año:
2014
Tipo del documento:
Article