Roles of ADAM17 in tumor metastasis and its molecular mechanism / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 721-724, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-466592
ABSTRACT
As an important member of the adisintegrin and metalloproteinase (ADAM) superfamily,ADAM17 can mediate a variety of membrane molecular hydrolysis off,such as adhesion molecules,cytokines,growth factors,etc,and play an important role in regulating tumor cell adhesion,apoptosis,metastasis and proliferation through the EGFR-PI3K-Akt pathway,Notch signaling pathway and other signaling pathways.The research of ADAM17 targeted drugs provides a new direction for cancer therapy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of International Oncology
Año:
2014
Tipo del documento:
Artículo
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