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Effect of Perioperative Perineural Injection of Dexamethasone and Bupivacaine on a Rat Spared Nerve Injury Model
The Korean Journal of Pain ; : 166-171, 2010.
Article en En | WPRIM | ID: wpr-46686
Biblioteca responsable: WPRO
ABSTRACT
BACKGROUND: Neuropathic pain resulting from diverse causes is a chronic condition for which effective treatment is lacking. The goal of this study was to test whether dexamethasone exerts a preemptive analgesic effect with bupivacaine when injected perineurally in the spared nerve injury model. METHODS: Fifty rats were randomly divided into five groups. Group 1 (control) was ligated but received no drugs. Group 2 was perineurally infiltrated (tibial and common peroneal nerves) with 0.4% bupivacaine (0.2 ml) and dexamethasone (0.8 mg) 10 minutes before surgery. Group 3 was infiltrated with 0.4% bupivacaine (0.2 ml) and dexamethasone (0.8 mg) after surgery. Group 4 was infiltrated with normal saline (0.2 ml) and dexamethasone (0.8 mg) 10 minutes before surgery. Group 5 was infiltrated with only 0.4% bupivacaine (0.2 ml) before surgery. Rat paw withdrawal thresholds were measured using the von Frey hair test before surgery as a baseline measurement and on postoperative days 3, 6, 9, 12, 15, 18 and 21. RESULTS: In the group injected preoperatively with dexamethasone and bupivacaine, mechanical allodynia did not develop and mechanical threshold forces were significantly different compared with other groups, especially between postoperative days 3 and 9 (P < 0.05). CONCLUSIONS: In conclusion, preoperative infiltration of both dexamethasone and bupivacaine showed a significantly better analgesic effect than did infiltration of bupivacaine or dexamethasone alone in the spared nerve injury model, especially early on after surgery.
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Texto completo: 1 Índice: WPRIM Asunto principal: Bupivacaína / Dexametasona / Cabello / Hiperalgesia / Neuralgia Límite: Animals Idioma: En Revista: The Korean Journal of Pain Año: 2010 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Bupivacaína / Dexametasona / Cabello / Hiperalgesia / Neuralgia Límite: Animals Idioma: En Revista: The Korean Journal of Pain Año: 2010 Tipo del documento: Article