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Effect of insulin on the expression of human urate transporter gene in renal proximal tubule epithelial HK-2 cells / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism ; (12): 282-284, 2015.
Artículo en Chino | WPRIM | ID: wpr-470524
ABSTRACT
Human proximal tubule epithelial cell line,HK-2 cells,were cultured with various concentrations of insulin for 48 h.Human urate transporter (hUAT) mRNA was detected by realtime quantitative PCR.hUAT mRNA levels were down-regulated by insulin (5,25,125,500 μIU/ml)in a dose-dependent manner (relative expression median were 0.95,0.40,0.24,and 0.23).In vitro,the expression of hUAT mRNA in HK-2 cells is associated with the concentration of insulin.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Endocrinology and Metabolism Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Endocrinology and Metabolism Año: 2015 Tipo del documento: Artículo