Event-related potentials of non-mediated obsessive-compulsive disorder patients in an emotional Stroop task / 中华行为医学与脑科学杂志

ABSTRACT

Objective To study the difference of attentional bias towards general negative words between non-mediated obsessive-compulsive disorder (OCD) patients and healthy controls.Methods Event-related potentials (ERPs) were collected from 26 non-mediated OCD patients and 24 normal controls while they performed an emotional Stroop task.Results Compared to healthy controls,OCD patients showed significantly longer reaction time (OCD(467 ± 14.88) ms,Controls(409.65 ± 15.49) ms,P＜ 0.01),and had significantly larger P2 and P3 amplitude to all three types of words (P2 amplitudeOCD(10.41±0.49) μV,Controls(8.89±0.48) μV,P＜0.05;P3 amplitude(10.04±0.68) μV,Controls(7.68±0.67) μV,P＜0.05).In addition,the P2 peak latency of the frontal area in OCD patients was significantly longer than that in healthy controls(OCD(190.09±4.71) ms,Controls(179.60±4.72) ms,P＜0.05).Conclusion Current findings suggest that OCD patients are characterized by a general attentional inhibition deficit but not an attentional bias to the negative words.