Status of serum vitamin B₁₂ and folate in patients with inflammatory bowel disease in China
Intestinal Research
; : 103-108, 2017.
Article
en En
| WPRIM
| ID: wpr-47073
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS: Inflammatory bowel disease (IBD) primarily involves the intestinal tract and can affect vitamin absorption. This study was designed to assess the prevalence of vitamin B₁₂ and folate deficiencies in patients with IBD, and to identify the risk factors associated with abnormal serum vitamin B₁₂ and folate levels. METHODS: We evaluated the medical records of 195 patients with Crohn's disease (CD) and 62 patients with ulcerative colitis (UC), and selected 118 healthy subjects for the control group. RESULTS: There were more CD patients with vitamin B₁₂ deficiency than UC patients (14.9% vs. 3.2%, P=0.014) and controls (14.9% vs. 4.2%, P=0.003). The prevalence of folate deficiency was higher in CD patients than in controls (13.3% vs. 3.4%, P=0.004). There were no significant differences in the serum vitamin B₁₂ and folate statuses of the UC and control groups. Patients with prior ileal or ileocolic resection showed a higher prevalence of abnormal vitamin B₁₂ levels than those without prior resection (n=6/16, n=23/179; P=0.018). A disease duration within 5 years was a risk factor of abnormal folate levels in CD patients. CONCLUSIONS: This study showed that vitamin B₁₂ and folate deficiencies were more common in patients with CD than in UC patients and controls. Prior ileal or ileocolonic resection was a risk factor of serum vitamin B₁₂ abnormalities, and a disease duration within 5 years was a risk factor of low serum folate levels in CD patients.
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Texto completo:
1
Índice:
WPRIM
Asunto principal:
Vitamina B 12
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Vitaminas
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Enfermedades Inflamatorias del Intestino
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Colitis Ulcerosa
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Enfermedad de Crohn
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China
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Registros Médicos
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Prevalencia
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Factores de Riesgo
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Absorción
Tipo de estudio:
Etiology_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Intestinal Research
Año:
2017
Tipo del documento:
Article