Comparison of Resovist and Gd-DTPA as susceptibility contrast agents for MR perfusion weighted imaging of hyperacute cerebral infarction in rats / 中国医学影像技术

ABSTRACT

Objective To compare the value on assessment of perfusion weighted imaging (PWI) using Gd-DTPA and the superparamagnetic iron oxide (SPIO) particles (Resovist) in the experimental model of hyperacute cerebral infarction in rats. Methods Thirty Wistar rats were randomly divided into Group A and B (each n=15). After occluding the left middle cerebral artery with thread for 1 h in all rats, two dynamic MR perfusion imaging series were acquired after intravenous bolus injections of 8 μmol Fe/kg SPIO (Group A) and 0.2 mmol/kg Gd-DTPA (Group B), respectively. The doses were chosen to obtain similar maximum signal change in normally perfused brain. The perfusion imaging was compared between the region of interest (ROI) in the core area with severe ischemia and in the penumbra area of moderate ischemia. The parameters were compared between two groups with pathologic findings and TTC stain. Results The first-passage profiles were found to be similar for Gd-DTPA and SPIO, both in the core area with severe ischemia and in the penumbra area of moderate ischemia of rats models. No statistical difference of the parameters (CBV, MTT, TTP) of PWI for ischemic penumbra was detected between Group A and B. Conclusion The efficacy of the Resovist using in the MR PWI is similar to Gd-DTPA for diagnosis of the perfusion reduction in the rat stroke models. Strong susceptibility effects may be achieved with small injection volumes. Resovist may play an important role in MR PWI.