Immobilized enzyme reactors in HPLC and its application in inhibitor screening: A review / 药物分析学报
Journal of Pharmaceutical Analysis
;
(6): 83-89, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-471774
ABSTRACT
This paper sets out to summarize the literatures based on immobilized enzyme biochromatography and its application in inhibitors screening in the last decade.In order to screen enzyme inhibitors from a mass of compounds in preliminary screening,multi-pore materials with good biocompatibility are used for the supports of immobilizing enzymes,and then the immobilized enzyme reactor applied as the inmobilized enzyme stationary phase in HPLC.Therefore,a technology platform of high throughput screening is gradually established to screen the enzyme inhibitors as new anti-tumor drugs.Here,we briefly summarize the selective methods of supports,immobilization techniques,co-immobilized enzymes system and the screening model.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Idioma:
Chino
Revista:
Journal of Pharmaceutical Analysis
Año:
2012
Tipo del documento:
Artículo
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