Analysis of 653 Patients with Gastritis Verrucosa / 天津医药

ABSTRACT

Objective:To investigate the clinical characteristic of gastritis verrucosa,and improving the recognition and treatment of this disease thereof.Methods:Six hundred and fifty three patients with gastritis verrucosa,who were diagnosed in Tianjin general hospital from March 2003 to February 2009,were studied.All of these patients were examined by electronic gastroscope and conducted biopsy.Patients were detected helicobacter pylori(HP)using 13C urea breath test.Fifty eight patients with HP-positive and fifty patients with HP-negative(moderate and serious grade),were collected and divided into two groups respectively.The patients in HP-positive groups were given lanseprazole(group A)or rabeprazole(group B).Furazolidone and amoxicilin were given in both groups.The patients in HP-negative groups were administered lanseprazole(group C)or cimetidine(group D).The effects of the treatment were observed in this study.Results:There was no specificity in clinical characteristic of gastritis verrucosa.The pathological changes of gastritis verrucosa were mostly located antrum.The pathological manifestations were chronic inflammation and chronic active inflammation with intestinal metaplasia or atypical hyperplasia.The positive rate of HP infection was 72.74%.There was significant different in the relationship between different levels of inflammation and HP infection(P ＜ 0.05).The effect of treatment was better in group A than that of group B(P ＜ 0.05);and better in group C than that in group D(P ＜ 0.05).Conclusion:There was a correlation between gastritis verrucosa and HP infection.The higher positive rate of HP was correlated with the degree of erosion.For patients with HP-positive,it is better to use the treatment of lansoprazole,amoxicillin and furazolidone.For patients with HP-negative,treatment with lanseprazole was better than cimetidine.