Chromosome 13 abnormalities and multiple myeloma / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
;
(12): 438-440, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-472419
ABSTRACT
With the development of FISH and other technique, the detection rate of chromosome abnormalities in multiple myeloma (MM) were increased. Chromosome 13 abnormalities is most common feature (about 50 %). The tumor suppressor gene and micro RNA on chromosome 13 play an important role on pathogenesis of MM. In the last decade, it is widely believed that chromosome 13 abnormalities is independent poor prognosis factor, but the recent more studies conform that its prognosis value is dependent on the other chromosome abnormalities. It is found that the new drugs such as bortezomib appear to reverse the poor prognosis conferred by chromosome 13 deletion.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Journal of Leukemia & Lymphoma
Año:
2010
Tipo del documento:
Artículo
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