Expression of PKC θ and Th1/Th2,Tc1/Tc2 cells cytokines of patients with myelodysplastic syndromes and aplastic anemia / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
;
(12): 401-404, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-472481
ABSTRACT
Objective To analyse expression levels of protein kinase C θ (PKC θ ) and its association with Th1/Th2,Tc1/Tc2 cytokines in peripheral blood mononuclear cells (PBMC) of patients with myelodysplastic syndromes and aplastic anemia (AA),and understand the pathogenesis of MDS and AA.Methods Fourteen patients with MDS-RA, fifteen patients with AA, and thirty health controls of PBMC were collected.mRNA expression levels of PKC θ were measured by RTQ-PCR,and the expression levels of Th1/Th2,Tc1/Tc2 cytokines were measured by the flow cytometry. Results The expression PKC θ mRNA (AA group23.54±1.01,MDS group23.76±1.58 ;health control group27.12±1.12, P=0.004) and Th1and Tc1cytokines were statistically significant of among groups (all P<0.05). Th2 and Tc2 cytokines were no statistical difference among groups (allP>0.05). There were no statistical difference in the PBMC of PKC θ mRNA and Th1/Th2,Tc1/Tc2 cell cytokine (allP>0.05) between MDS and AA.Conclusions The expression levels of PKCθmRNA and Th1,Tc1cells correlated cytokine in MDS and AA patients of PBMC are increases.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Leukemia & Lymphoma
Año:
2012
Tipo del documento:
Artículo
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