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Risk Factors for Atherosclerosis in Elderly Patients with Impaired Glucose Tolerance / 天津医药
Tianjin Medical Journal ; (12): 180-182, 2010.
Artículo en Chino | WPRIM | ID: wpr-472736
ABSTRACT

Objective:

To determine the risk factor for early stage atherosclerosis in elderly patients with impaired glucose tolerance(IGT).

Methods:

One hundred patients were divided into 2 groups,experimental group(IGT,n=50)and control group(NGT,n=50).Patients in both groups underwent high-frequency Doppler echocardiography to evaluate intima-media thickness(IMT)of carotid artery and flow-mediated diastolic function(FMD)of brachial artery,which was indicated by diastolic inner diameter changing rate(D %).The values were measured in both groups of including body height,body weight,waist line,hip line,blood pressure,fasting plasma glucose(FPG),two hours plasma glucose(2hPG),fasting insulin(FINS),triglyceride(TG),total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C),high density lipoprotein-cbolesterel(HDL-C),high sensitive C-reactive protein(hs-CRP),nitrogen monoxidum(NO),body mass index(BMl),waist-to-hip ratios(WHR),and insulin resistance index with homeostasis model(HOMA-IR).The association between all of the parameters and IMT,and the risk factors for the carotid artery were analysed in IGT group.

Results:

The values of BMI,WHR,2hPG,TG,LDL-C,hs-CRP,FINS and IMT of carotid artery were significantly increased in IGT group compared with those of the NGT group.Conversely,NO,HOMA-IR and D% were significantly decreased in IGT group than those of NGT group(P < 0.05 or P < 0.01).There was positive correlation between carotid-IMT and the age,BMI,WHR,2hPG,TC,LDL-C,hs-CRP and HOMA-IR in IGT group(P <0.05 or P < 0.01).Inversely,there was negative correlation between carotid-IMT with D% in IGT group(P < 0.01).The risk factors for carotid-IMT were age,WHR,HOMA-IR and D%.

Conclusion:

Elderly patients with IGT have already had risk factors for early stage atherosclerosis,including age,concentric obesity,insulin resistance,and impaired endothelial function.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Idioma: Chino Revista: Tianjin Medical Journal Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Idioma: Chino Revista: Tianjin Medical Journal Año: 2010 Tipo del documento: Artículo