The clinical significance of c-myb gene on the development of colorectal cancer / 肿瘤研究与临床

ABSTRACT

C-myb is a member of the myb transcription factor family and involved in cell proliferation and differentiation.It activates specific target genes to regulate specific program through certain channel,and it takes signal transduction to regulate function and expression of protein.In this paper,c-myb,by binding to Wnt signaling pathway,makes Lgr5 start to promote cell proliferation and differentiation,and it can serve as a new therapeutic target to provide the basis of early diagnosis and treatment for colorectal cancer.