Effect on the Akt2 in Skeletal Muscle of Rats with Insulin Resistance Treated by Acupuncture / 针灸推拿医学(英文版)
Journal of Acupuncture and Tuina Science
;
(6): 277-281, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-473317
ABSTRACT
Objective:
To observe the effect of acupuncture on Akt2 mRNA expression in skeletal muscle of insulin resistant rat models.Methods:
Twenty-four SD rats were randomly divided into a control group, a model group and an acupuncture group. Fasting plasma glucose (FPG), fasting insulin (FINS), insulin sensitivity index (ISI), C peptide (C-P), as well as Akt2 mRNA expression in skeletal muscle of rats were detected by glucose oxidase method, ELISA and real-time PCR.Results:
Compared with the control group, the level of FPG, FINS and C-P increased significantly (P<0.01) while ISI and Akt2 mRNA expression decreased markedly in the model group (P<0.01, P<0.05). In the acupuncture group, the levels of FPG, FINS and C-P were much lower than in the model group (P<0.01, P<0.01,P<0.05) and ISI and Akt2 mRNA expression increased markedly (P<0.01).Conclusion:
The mechanism of acupuncture in treating insulin resistance may relate to the up-regulated of the Akt2 mRNA expression and to the improvement of the signal transduction of PI3K pathway.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Acupuncture and Tuina Science
Año:
2010
Tipo del documento:
Artículo
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