Epstein-Barr virus infection and development of T-cell lymphoma / 白血病·淋巴瘤

ABSTRACT

Epstein-Barr virus (EBV) is a kind of DNA tumor virus. Previous Studies on the tumorigenic mechanism of EBV mainly focus on human B lymphocyte. Now there are evidences that EBV exists in human T-cell lymphoma. Exploration in recent years show that EBV could infect T lymphocyte and likely play an important role in the pathogenesis of T-cell lymphoma. Investigation of molecular biological effect of LMP1 in T cell will be helpful for us to understand the approach and mode of EBV infecting T lymphocyte as well as the mechanism of T-cell lymphoma development.