Interactions between chitosan nanoparitcles and cells by surface plasmon resonance technology / 国际药学研究杂志

ABSTRACT

Objective Using surface plasmon resonance (SPR)technology to monitor the interactions between chitosan nanoparticles (CS-NP)and biomembrane. Methods SPR signals induced by CS-NP,chitosan molecules and thymopentin(TP5) molecules in living C6 cells were detected and analyzed by the SPR-based cytosensor. Results The signal began to increase within 30 min after the addition of CS-NP or chitosan molecules. These responses were strongly dependent on the concentrations of CS. However,the signal did not change after the addition of TP5 molecules. Conclusion SPR technology can clarify the interaction between nanoparticles and biomembrane in real time.