Relationship between aoiponectin receptor 1 gene + 10225C/G variant and type 2 diabetes / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
;
(12): 17-19, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-474656
ABSTRACT
Objective To investigate the relationship between single nucleotide polymorphism (SNP) at position + 10225 in adiponectin receptor 1 gene and type 2 diabetes.Methods The genotypes of + 10225C/G of adiponectin receptor 1 were detected by polymerase chain reaction with sequence specific primers (PCR-SSP) in 200 type 2 diabetes and 100 health controls.Fasting blood samples of all cases were obtained to extract DNA and detect genotype.Statistical software spss 13.0 was used to analyzed.Results Frequency of G-type allele in type 2 diabetes was 40.5%,that in normal controls was 23.5%,there was significant diffierences in the genotype frequencies of SNP+10225 between type 2 diabetes and health controls (x2 =128.0,P<0.01).Conclusion AdipoR1 + 10225C/G polymorphism was probably associated with type 2 diabetes,G-type allele might be a genetic risk factor of type 2 diabetes.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Primary Medicine and Pharmacy
Año:
2015
Tipo del documento:
Artículo
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