The expression of MMP-1 and MMP-2 of periodontal ligament fibroblasts treated by tea polyphenols and LPS / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6): 774-777, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-475211
ABSTRACT
Objective:
To survey the expression of MMP-1,MMP-2 of human periodontal ligament cells(HPDLCs)treated by tea polyphenols(TP)and lipopolysaccharide(LPS).Methods:
HPDLCs were in vitro cultured in vitro and treated by TP(200 μg/ml) and /or LPS(100 μg/ml)for 24,48 and 72 h respectively,the secretion of MMP-1 and MMP-2 were examined by ELISA,MMP-1 and MMP-2 mRNA expression was examined by real-time PCR.Results:
The secression and mRNA expression of MMP-1 and MMP-2 of HPDLCs increased by LPS treatment and significantly inhibited by TP at the different times.Conclusion:
TP can inhibit the col-lagen degradation of HPDLCs mediated by LPS.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Practical Stomatology
Año:
2014
Tipo del documento:
Artículo
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