Influence of nitroglycerin atomizing inhalation on vascular endothelial function in patients with pulmo-nary heart disease onset / 心血管康复医学杂志

ABSTRACT

Objective:To explore influence of nitroglycerin atomizing inhalation on vascular endothelial function in patients with pulmonary heart disease (PHD)onset.Methods:A total of 94 patients with PHD onset visiting to our hospital were randomly and equally divided into routine treatment group and atomizing inhalation group (inhalation group,received nitroglycerin atomizing inhalation based on routine treatment).Mean pulmonary arterial pressure (mPAP),blood gas analysis and score of clinical symptoms were observed.Results:Compared with routine treat-ment group,after treatment,there were significant reductions in mPAP [(27.97±3.42)mmHg vs.(23.21±3.34) mmHg],arterial partial pressure of carbon dioxide [PaCO2 ,(49.66±8.21)mmHg vs.(45.37±8.12)mmHg],en-dothelin-1 [ET-1,(53.45±15.11)pg/L vs.(46.21 ± 15.35)pg/L]level,and clinical symptom score [(7.69± 2.65)scores vs.(5.41±2.49)scores];and significant rise in arterial partial pressure of oxygen [PaO2 ,(76.14± 8.65)mmHg vs.(82.01±8.41)mmHg]and NO level [(63.94±12.85)μmol/L vs.(70.94±13.95)μmol/L],to-tal effective rate (63.83% vs.87.23%),P <0.05 or <0.01 in inhalation group.Conclusion:Nitroglycerin atomi-zing inhalation can significantly improve vascular endothelial function,raise therapeutic effect in treatment of pul-monary heart disease.