MYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia
Annals of Laboratory Medicine
;
: 289-293, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-47749
ABSTRACT
MYC rearrangement, a characteristic cytogenetic abnormality of Burkitt lymphoma and several subsets of other mature B-cell neoplasms, typically involves an immunoglobulin gene partner. Herein, we describe a case of precursor B-cell lymphoblastic leukemia harboring a MYC rearrangement with a novel non-immunoglobulin partner locus. The patient was a 4-yr-old Korean boy with ALL of the precursor B-cell immunophenotype. At the time of the second relapse, cytogenetic analyses revealed t(4;8)(q31.1;q24.1) as a clonal evolution. The MYC rearrangement was confirmed by FISH analysis. He died 3 months after the second relapse without achieving complete remission. To our knowledge, this is the first report of a case of MYC rearrangement with a non-immunoglobulin partner in precursor B-cell lymphoblastic leukemia.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Recurrencia
/
Translocación Genética
/
Cromosomas Humanos Par 4
/
Cromosomas Humanos Par 8
/
Inmunoglobulinas
/
Células de la Médula Ósea
/
Leucemia-Linfoma Linfoblástico de Células Precursoras B
/
Proteínas Proto-Oncogénicas c-myc
/
Sitios Genéticos
/
Cariotipificación
Límite:
Child, preschool
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Annals of Laboratory Medicine
Año:
2012
Tipo del documento:
Artículo
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