Clinical value of plasma (1,3)-β-D-glucan in the detection of invasive fungal infections / 中国基层医药

ABSTRACT

Objective To discuss the clinical value of plasma (1,3)-β-D -glucan detection (G test) for early diagnosis of invasive fungal infections (IFI).Methods A total of 180 cases of IFI were divided into suspec-ted group (84 cases),diagnosed group (49 cases)and clinical diagnosis group (47 cases).At the same period,the other 44 hospitalization patients with bacterial infection and 53 healthy persons were selected.All personnel were par-ticipated in the experiment using the MB -80 system for rapid detection of microbial dynamic detection,simultaneous plasma G test was evaluated using ROC curve analysis G optimal threshold test.Results Candida albicans was a common respiratory infections of IFI.Compared with bacterial group (9.4pg/mL)and normal group (7.8pg/mL) plasma glucan content median,IFI group plasma G test (29.3pg/mL)was significantly higher,and the differences were statistically significant(Z =-2.41,P =0.015;Z =-2.19,P =0.028),Compared with the median plasma glu-can content of the diagnosis group (105.8pg/mL)and clinical diagnosis group (46.3pg/mL),to be diagnosed group (8.1pg/mL)was significantly lower,and the differences were statistically significant(Z =-2.99,P =0.003;Z =-2.19,P =0.027).ROC curve analysis showed that when the cutoff value was 9.35pg/mL,its specificity (67.2%), sensitivity (70.3%)and negative /positive predictive value (69.3% /65.8%)were the best,and more consistent with the culture method,the Kappa value was 0.603,the difference was statistically significant (P =0.036 ). Conclusion In the early diagnosis of IFI,plasma G test has good results and can be widely used.