Research of the relationship between FIB with ACS and severity of the ACS / 实用医学杂志

ABSTRACT

Objective Serum FIB has been established as a predictor of cardiovascular events. The aim of this study was to investigate the relationship of FIB with acute coronary syndrome (ACS) and severity of the ACS. Methods A total of 692 patients with ACS who underwent a definite diagnosis were selected. Ninety-nine patients without coronary heart disease severed as control group. Detail information were recorded in age, gender, history of alcoholic, smoking, hypertension. All patients were detected in FIB and some other biochemical indicators levels. Use the correlation analysis to find the relationship of FIB with grace scoring. Results With the increase of Grace risk level and coronary artery lesions and myocardial ischemia,the levels of FIB were significantly increased (P < 0.05).The correlation analysis showed that Grace scores had a positive correlation with FIB in ACS patients. The logistic regression analysis showed the FIB was the most prominent predictors for ACS. The areas under the ROC curve of FIB were 0.87 which suggested that FIB had a higher predictive value of ACS. Conclusion The levels of serum FIB is closely related to criticality of ACS. For the ACS patients,higher levels of FIB indicated higher Grace scores. FIB level may have important clinical value in early risk stratification evaluation of prognosis and treatment options.