The stiffness of primary liver cancer:the relationship between virtual touch tissue quantification and collagen ;percentage assay / 中华超声影像学杂志

ABSTRACT

Objective To study the relativity between virtual touch tissue quantification(VTQ)and collagen percentage assay in the stiffness of primary liver cancer(PLC).Methods Forty patients with PLC were examined with virtual touch tissue quantification (VTQ)to obtain the shear wave velocity(SWV) before operation.These parameters were compared with collagen percentage assay counted with immunohistochemistry,and the correlation was statistically studied.Results Significant differences in mean SWV appeared between tumor tissues and background liver tissues of these PLC [2.82 ± 0.68 )m/s vs (1 .66±0.47)m/s,P <0.05].The collagen percentage assay of tumor tissues was significantly higher than that of background liver tissues [Sirius red group:(74.68 ± 1 1 .29)% vs (41 .59 ± 1 7.85 )%,P < 0.05;Masson group:(75.47 ± 1 1 .1 1 )% vs (40.41 ± 1 7.12 )%,P < 0.05 ].The SWV before operation was correlated positively to collagen percentage assay (Sirius red group:r =0.70,P <0.05;Masson group:r =0.73,P < 0.05 )of histological section after operation.Conclusions SWV value calculated by VTQ has reasonable correlation with collagen percentage assay of tumors,it is a valuable index for quantitative evaluation of the stiffness of liver cancer.