The effect of seabuckthorn flavonoids against ultraviolet injury / 重庆医学

ABSTRACT

Objective Through the UVB rays radiation skin injury model ,the study investigated the effect of seabuckthorn flavonoids on the protection and restoration of the skin ,in order to provide experimental basis of looking for the new drugs against ultraviolet injury .Methods By UVB radiating repeatedly ,the study built UVB radiation skin injury model in mice ,to observed the morphological changes of the skin in every groups of experimental animal ,the super oxide dismutase (SOD) activity of the skin and the peroxidation damage degree of the skin lipid ,which is also the content changes of malondialdehyde (MDA) and collagen .Results The change of model group whose epidermis layer increased and the dermis thickened was more obvious than the normal group ,so the UVB radiation skin injury model was built successfully .The model group compared with the normal group ,its SOD activity was significantly lower and its MDA content was significantly higher (P< 0 .01) .However ,the SOD activities of positive control group and being fed with seabuckthorn flavonoids group were significantly higher and their MDA contents were significantly lower (P<0 .01) .The model group compared with the normal group ,its collagen content was significantly lower (P< 0 .05) ,and the collagen contents of positive control group and being fed with seabuckthorn flavonoids group were higher ,whose difference was extremely significant(P< 0 .01) .However ,the positive control group had hyperplastic scar .Conclusion Seabuckthorn flavonoids had the fol‐lowing effectspreventing the UVB repeating radiation damage to the skin ,improving the SOD activity of skin tissue and the colla‐gen content ,inhibiting the increase of MDA content and scar hyperplasia ,and having antagonism effect of UVB causing mice skin photoaging .