The Efficacy of a Leukotriene Receptor Antagonist and a Second-generation Anti-histamine in the Treatment for Children with Moderate to Severe Persistent Allergic Rhinitis / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
; : 158-166, 2008.
Article
en Ko
| WPRIM
| ID: wpr-48013
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: We evaluated the efficacy of leukotriene receptor antagonist and second generation anti-histamine in children with moderate to severe persistent allergic rhinitis. METHODS: Twenty eight patients who were treated with second generation anti-histamine for 4 weeks (Zyrtec syrup(R), Group A) and 58 patients who were treated with leukotriene receptor antagonist for 4 weeks (Singulair(R), Group B) were enrolled in this study. Control group (n=22) was received only first generation anti-histamine (Hydroxyzine) intermittently. Efficacy were evaluated by nasal scores in nasal congestion, rhinorrhea, nasal itching, sneezing and total nasal symptom score (a sum of patient ratings of nasal congestion, rhinorrhea, nasal itching, sneezing) before treatment and at 2 and 4 weeks after treatment. RESULTS: There were no difference in the total IgE and total eosinophil count of 3 groups. There were also no significant difference in the initial symptom scores. For nasal congestion, group A and B showed significant improvement at 2 and 4 weeks after treatment compared with controls (each P=0.006, P=0.000, P=0.023, P=0.001). For sneezing, group A and B showed significant improvement at 2 weeks after treatment compared with controls (each P=0.048, P=0.011) and group B also showed significant improvement at 4 weeks after treatment compared with controls (P=0.041). In total nasal symptom score (TNSS), group A and B showed significant improvement at 2 and 4 weeks after treatment compared with controls (each P=0.014, P=0.005, P=0.008, P=0.005). CONCLUSION: In the moderate to severe persistent allergic rhinitis, leukotriene receptor antagonist or second generation anti-histamine is effective in nasal congestion and sneezing.
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Índice:
WPRIM
Asunto principal:
Prurito
/
Estornudo
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Inmunoglobulina E
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Rinitis
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Rinitis Alérgica Perenne
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Receptores de Leucotrienos
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Estrógenos Conjugados (USP)
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Eosinófilos
Límite:
Child
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Humans
Idioma:
Ko
Revista:
Pediatric Allergy and Respiratory Disease
Año:
2008
Tipo del documento:
Article