Antioxidant activity of an exopolysaccharide from cultivated Cordyceps sisnensis fungus / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 370-373, 2009.
Article
en Zh
| WPRIM
| ID: wpr-480396
Biblioteca responsable:
WPRO
ABSTRACT
Aim:
To preliminarily investigate the antioxidant activity of the acidic exopolysaccharide(EPS-A) from cultivated Cordyceps sisnensis in vitro and in vivo.Methods:
PC12 cells were injured by H_2O_2 after the cells were treated with different doses of EPS-A for 6 h, and then the levels of malondialdelyde( MDA) and superoxide dis-mutase (SOD) in PC12 cells were determined. H22 cells were inoculated into the right oxter of each mouse after ICR mice were treated with EPS-A for 7 days, and tumor-bearing mice were treated with EPS-A for 7 days. MDA level and SOD activity in liver, brain and serum were assayed, and tumor weight of each mouse was measured as well.Results:
EPS-A significantly decreased the production of MDA and increased SOD activity in H_2O_2-injured PC12 cells. Moreover, EPS-A inhibited H22 tumor growth in mice, in which the level of MDA in liver and brain was reduced, and SOD activity in liver, brain and serum was enhanced.Conclusion:
EPS-A exhibited antioxidant activity in cell cultures and mice.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Journal of China Pharmaceutical University
Año:
2009
Tipo del documento:
Article