Clinical efficacy and safety of lamotrigine monotherapy in newly diagnosed pediatric patients with epilepsy / 소아과
Korean Journal of Pediatrics
;
: 565-569, 2010.
Artículo
en Coreano
| WPRIM
| ID: wpr-48190
ABSTRACT
PURPOSE:
To verify the efficacy and safety of lamotrigine (LTG) monotherapy in newly diagnosed children with epilepsy.METHODS:
We prospectively enrolled 148 children who had undergone LTG monotherapy at our institution between September 2002 and June 2009. Twenty-nine patients were excluded 19 due to incomplete data and 10 were lost to follow up. The data of the remaining 119 patients was analyzed.RESULTS:
We enrolled 119 pediatric epilepsy patients (aged 2.8-19.3 years; 66 males and 53 females) in this study. Out of 119 patients, 29 (25.2%) had generalized epilepsy and 90 (74.8%) had partial epilepsy. The responses of seizure reduction were as follows Seizure freedom (no seizure attack for at least 6 months) in 87/111 (78.4%, n=111) patients; partial response (reduced seizure frequency compared to baseline) in 13 (11.7%) patients; and persistent seizure in 11 (9.9%) patients. The seizure freedom rate was in 81.6% in patients with partial seizure (75.9% for complex partial seizure and 90.9% for benign rolandic epilepsy) and 44.8% in patients with generalized epilepsy (30.0% for absence seizure, 35.7% for juvenile myoclonic epilepsy patients, and 100.0% for idiopathic generalized epilepsy patients). Adverse reactions were reported in 17 (14.3%) patients, and 8 patients (6.7%) discontinued LTG because of rash and tic. No patient experienced severe adverse reaction such as Stevens-Johnson syndrome.CONCLUSION:
LTG showed excellent therapeutic response and had few significant adverse effects. Our findings report may contribute in promoting the use of LTG monotherapy in epileptic children.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Convulsiones
/
Triazinas
/
Estudios Prospectivos
/
Síndrome de Stevens-Johnson
/
Epilepsias Parciales
/
Epilepsia Generalizada
/
Epilepsia Tipo Ausencia
/
Epilepsia Mioclónica Juvenil
/
Tics
/
Epilepsia
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
Límite:
Niño
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Pediatrics
Año:
2010
Tipo del documento:
Artículo
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