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Prevalence of Major Methicillin-Resistant Staphylococcus aureus Clones in Korea Between 2001 and 2008
Annals of Laboratory Medicine ; : 536-541, 2016.
Artículo en Inglés | WPRIM | ID: wpr-48263
ABSTRACT

BACKGROUND:

Methicillin-resistant Staphylococcus aureus (MRSA) are important pathogens causing nosocomial infections in Korean hospitals. This study aimed to investigate the epidemiological and genetic diversity of clinical S. aureus isolates in healthcare settings from 2001 to 2008.

METHODS:

Samples and data were obtained from 986 individuals as part of the National Antimicrobial Surveillance Project, involving 10 regions nationwide. Molecular typing studies, including multilocus sequence typing (MLST) and staphylococcal cassette chromosome mec (SCCmec) typing were performed, and a representative clone of Korean MRSA was classified by combinational grouping using a DiversiLab (DL; bioMérieux, France) repetitive element polymerase chain reaction (rep-PCR) system.

RESULTS:

Nine Korean MRSA clones (KMRSA-1 to -9) were identified by analysis of genetic backgrounds and molecular characteristics. KMRSA-1 to -3, expressing clonal complex (CC) 5 (carrying SCCmec II), CC8 (carrying SCCmec III), and CC72 (carrying SCCmec IV) were spread nationwide. In contrast, KMRSA-6 was highly prevalent in Gyeongsangnam-do, and KMRSA-4 was highly prevalent in Jeollanam-do and Jeollabuk-do.

CONCLUSIONS:

Epidemic KMRSA clones were genetically similar to major clones identified from the USA, with the exception of KMRSA-2, which had the SCCmec III type. Our results provide important insights into the distribution and molecular genetics of MRSA strains in Korea and may aid in the monitoring of MRSA spread throughout the country.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Infecciones Estafilocócicas / Proteínas Bacterianas / ADN Bacteriano / Prevalencia / Electroforesis en Gel de Campo Pulsado / Staphylococcus aureus Resistente a Meticilina / República de Corea / Tipificación de Secuencias Multilocus / Reacción en Cadena de la Polimerasa Multiplex / Hospitales Tipo de estudio: Estudio de prevalencia / Estudio pronóstico / Factores de riesgo Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Annals of Laboratory Medicine Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Infecciones Estafilocócicas / Proteínas Bacterianas / ADN Bacteriano / Prevalencia / Electroforesis en Gel de Campo Pulsado / Staphylococcus aureus Resistente a Meticilina / República de Corea / Tipificación de Secuencias Multilocus / Reacción en Cadena de la Polimerasa Multiplex / Hospitales Tipo de estudio: Estudio de prevalencia / Estudio pronóstico / Factores de riesgo Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Annals of Laboratory Medicine Año: 2016 Tipo del documento: Artículo