Protective effects of quercetin on the periodontal tissue in rats with periodontitis / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6): 619-622, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-482718
ABSTRACT
Objective:
To investigate the protective effects of quercetin on the periodontal tissue in Wistar rats with periodontitis.Methods:
30 Wistar rats were randomly divided into 3 groups(n =1 0)Control group (group N),ligation group(group L)and liga-tion +quercetin group(group LQ).Bilateral first molars of the rats in group L and LQ were cervically ligated by an orthodontic wire with the diameter of 0.2 mm.The rats in group LQ were then treated with quercetin by gavage at 50 mg/(kg·d)after ligation.After 8 weeks,the rats were killed.Continuous slices of the periodontal tissue were made for HE staining and immunohistochemistry stai-ning.The morphological changes and the expression of TNF-αand COX-2 in the periodontal tissue were observed under light micro-scope.Results:
The inflammatory cells and periodontal pocket were observed in group LQ were less than those in group L.The levels of TNF-α,COX-2 in group LQ were lower than that those in the group L(P <0.05).Conclusion:
Quercetin has a protective effect on the periodontal tissues of Wistar rats with periodontitis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Practical Stomatology
Año:
2015
Tipo del documento:
Artículo
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