Recent advances in the quantification of drug metabolizing enzymes and transporters by proteomic approach / 药学学报
Acta Pharmaceutica Sinica
; (12): 668-74, 2015.
Article
en Zh
| WPRIM
| ID: wpr-483377
Biblioteca responsable:
WPRO
ABSTRACT
With the advance of drug development and research techniques, the drug metabolic processes and mechanism can be more deeply achieved. As the drug metabolism and pharmacokinetics process are mediated by drug metabolizing enzymes and transporters, study of drug metabolizing enzymes and transporters has become an important part for drug development. The traditional immunoassays with low sensitivity and poor specificity can not reflect the accurate expression level of drug metabolizing enzymes and transporters. We now give a brief review on the quantitative study of drug metabolizing enzymes and transporters by mass spectrometry-based proteomic approach.
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WPRIM
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2015
Tipo del documento:
Article