Research on progress on presbycusis based on cell apoptosis / 中国医学装备

ABSTRACT

Several proteins associated with apoptosis were analyzed to investigate the progress of presbycusis based on cell apoptosis. Four proteins of caspase-3, XIAP, Sir2 T1 and cytochrome C which were associated with apoptosis were selected. Influence and progress of four proteins on presbycusis were analyzed. Apoptosis is the key factor which causes presbycusis, including apoptosis of cochlear hair cells, cochlear spiral ganglion cells and primary auditory cortical neuron. There is a close relationship between the four proteins and apoptosis of hearing related cells. These four kinds of protein factors played a role in the progress of presbycusis and are expected to serve as a target for the treatment of presbycusis.