Genetic controls of Th17 cell differentiation and plasticity
Experimental & Molecular Medicine
; : 1-6, 2011.
Article
en En
| WPRIM
| ID: wpr-48420
Biblioteca responsable:
WPRO
ABSTRACT
CD4+ T lymphocytes play a major role in regulation of adaptive immunity. Upon activation, naive T cells differentiate into different functional subsets. In addition to the classical Th1 and Th2 cells, several novel effector T cell subsets have been recently identified, including Th17 cells. There has been rapid progress in characterizing the development and function of Th17 cells. Here I summarize and discuss on the genetic controls of their differentiation and emerging evidence on their plasticity. This information may benefit understanding and treating immune diseases.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Factores de Transcripción
/
Transcripción Genética
/
Linfocitos T CD4-Positivos
/
Diferenciación Celular
/
Regulación de la Expresión Génica
/
Citocinas
/
Linfocitos T Reguladores
/
Células Th2
/
Células TH1
/
Linaje de la Célula
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Experimental & Molecular Medicine
Año:
2011
Tipo del documento:
Article