DJ-1 regulates the function of mitochondria in Parkinson’s disease / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 22-26, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-484243
ABSTRACT
Mitochondrial dysfunction plays an important role in the process of PD, DJ-1 participates in regulating the function of mitochondria,which has an effect on the protection of mitochon-dria. DJ-1 mutations can lead to the decrease of the activity of mitochondrial complex Ⅰ, the decrease of mitochondrial mem-brane potential and then mitochondrial fragmention and mitoph-agy, and then further damage neurons and trigger PD. This re-view presents the role of DJ-1 in regulating the function of the mitochondria in the pathogenesis of Parkinson's disease(PD).
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmacological Bulletin
Año:
2016
Tipo del documento:
Artículo
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