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Predictive Value of Inflammatory Factors on All Cause Mortality in Normal Population:6.9 Years Follow-up Results in Kailuan Group for 83,000 Subjects / 中国循环杂志
Chinese Circulation Journal ; (12): 245-249, 2016.
Artículo en Chino | WPRIM | ID: wpr-484469
ABSTRACT

Objective:

To explore the predictive value of inlfammatory factors on all cause mortality in normal population.

Methods:

In our prospective cohort study, a total of 83,228 subjects from physical examination of Kailuan group from 2006-07 to 2007-10 were enrolled, nobody had acute inlfammation. The death information was collected once per year and the last follow-up was conducted in 2013-12-31. According to baseline levels, white blood cells (WBC), ratio of neutrophil/lymphocyte ratio (N/L) and C-reactive protein (CRP) were respectively divided into 4 Quartile groups; all cause mortality was compared among different groups and their risks were studied by multi-Cox regression analysis.

Results:

The average follow-up time was 6.9 years. All cause mortality in Quartile 1, Quartile 2, Quartile 3 and Quartile 4 groups for WBC were 4.2%, 4.5%, 4.5% and 5.0% respectively; for N/L were 3.3%, 3.6%, 4.5% and 6.7% respectively; for CRP were 3.0%, 3.6%, 4.8% and 6.8% respectively. Multi-Cox regression analysis indicated that with adjusted age, gender, waist and other confounders, by elevation of WBC, N/R and CRP, the risks of all cause mortality were increased accordingly, and the risks in Quartile 4 groups were higher than those in Quartile 1 groups as for WBC, it was 1.17-time (95% CI 1.06-1.29);for N/L, it was 1.44-time (95% CI 1.31-1.59); for CRP, it was 1.33-time (95% CI 1.20-1.47) respectively.

Conclusion:

Elevated WBC, N/R and CRP are independent risk factors for all cause mortality in normal population.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Idioma: Chino Revista: Chinese Circulation Journal Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Idioma: Chino Revista: Chinese Circulation Journal Año: 2016 Tipo del documento: Artículo