The effect of Huangqi injectionon theimmune function and myocardial enzymes of the children with viral myocarditis / 国际中医中药杂志

ABSTRACT

ObjectiveTo investigate the effect of Huangqiinjection on the immune function of cardiomyocytes and myocardial enzymes of the children with viral myocarditis.MethodsA total of 86 patients who met the inclusion criteria of viral myocarditis were randomized into two groups. Fourty-onepatients in the control group took 1, 6 Fructose Diphosphate (FDP), and 86 patients of the treatment group tookHuangqi injection based on the intervention of control group. Both groups were treated for three weeks. The main outcomes were myocardial enzymes and immune function of cardiomyocytes.ResultsTotal effective rate of treatment group was significantly higher than the control group (95.56%vs. 80.49%;χ2=4.740,P<0.05). After treatment, the levels of CD3+ (64.9% ± 8.8%vs. 52.7% ± 8.2%,t=6.633), CD4+ (41.7% ± 6.5%vs.37.3% ± 7.2%,t=2.978), CD8+ ( 28.9% ± 4.2%vs.26.4% ± 4.3%,t=2.726) of treatment group were siginificantly higher than the control group (P<0.05). The CK (129.7 ± 29.8 U/Lvs. 167.7 ± 34.5 U/L,t=-5.479), CK-MB (12.7 ± 4.2 U/L vs.18.9 ± 6.2 U/L,t=-5.472), LDH (165.3± 38.4 U/Lvs.197.2 ± 46.3 U/L,t=-3.489), cTnⅠ(0.129 ± 0.012μg/Lvs. 0.204 ± 0.071μg/L,t=-6.981) of treatment group were significantly lower than the control group (P<0.05). Conclusion Huangqiinjection can significantly improve the clinical efficative rates, the immune function of cardiomyocytes and reduce the myocardial enzymes of children with viral myocarditis.