Toll-like receptors in hematological malignancies / 肿瘤研究与临床

ABSTRACT

The Toll-like receptors are a kind of pattern recognition receptors,which are expressed in a variety of cells,playing an important role in innate immunity and subsequent acquired immunity.At the same time,they are also involved in the immunity,proliferation,apoptosis and other physiological processes of the cells.Toll-like receptors are also expressed in hematological malignancies and involved in the progress of tumor development,immune escape,resistance,which play a double-edged sword role.In this paper,basic knowledge of TLR molecule and study on hematological tumor were mainly reviewed,aiming to provide a train of thoughts for the treatment of hematologic malignancies.