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Effect of curcumin on spinal cord injury repair via inhibiting NF-κB signalling pathway:research progress / 中国药理学与毒理学杂志
Article en Zh | WPRIM | ID: wpr-487403
Biblioteca responsable: WPRO
ABSTRACT
Inflammation response is the most crucial link in the pathogeneses of spinal cord injury (SCI),and is the basis of secondary damage. NF-κB Signalling pathway is activated excessively after SCI,so that numerous NF-κB possessing biological activities is quickly translocated into the nuclear and regulates the target genes,resulting in heightened inflammation and further tissue damage. Suppressing NF-κB signalling pathway and controlling inflammation response effectively are effective approaches to promoting SCI repair. It is found that curcumin has multiple target molecules to suppress NF-κB signalling pathway,block the excessive activation of NF-κB and reduce the expression of proinflammation cytokines,which plays an important role in SCI repair. This article discusses NF-κB signalling pathway,the contribution of NF-κB signalling pathway to SCI and the role of curcumins inhibition of NF-κB signalling pathway in SCI.
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Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Journal of Pharmacology and Toxicology Año: 2016 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Journal of Pharmacology and Toxicology Año: 2016 Tipo del documento: Article