Retrospective Analysis of Epstein Barr Virus or Cytomegalovirus Infection in Patients with Systemic Lupus Erythematosus / 现代检验医学杂志

ABSTRACT

Objective To analyze the epidemiological characteristics of Epstein Barr virus (EBV)or cytomegalovirus (CMV) infection in systemic lupus erythematosus (SLE)patients in order to provide reference for clinic.Methods The clinical data of 202 female cases in-patients diagnosed with SLE (SLE group)from January 2012 to May 2015 in Nanjing Drum Tower Hospital were analyzed retrospectively.Meanwhile,203 cases including female renal transplant donors,obstetrics and gyne-cology in-patients selected randomly were enrolled as control group.The infection rate between SLE and control groups was analyzed and compared based on the results of EBV-DNA and CMV-DNA in peripheral blood quantified by real time PCR. Results The positive rate of EBV-DNA in SLE group was 11.39% (23/202),with significantly statistical difference when comparing with the control group [3.45% (6/174)](χ2 = 8.28,P < 0.01).The positive rate of CMV-DNA [7.92% (16/202)]was significantly higher than that in control group [1.97% (4/203)](χ2 =7.64,P <0.05).In addition,the positive rate of EBV-DNA and CMV-DNA was also greatly higher in reproductive-age (20~45 years old)of SLE patients than those in control group,10.94%(14/128)vs 3.45%(4/116)(χ2 =4.99,P <0.05)and 7.75%(10/129)vs 2.22%(3/135)(χ2 =4.31,P <0.05),respectively.Conclusion SLE patients were more inclined to be accompanying infected by EBV or CMV, indicating the possible correlation between SLE and EBV or CMV infection;and physicians should pay more attention to the viral infection of SLE in clinical treatment.