Strategy of antibody-drug conjugates in preclinical safety evaluation / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
; (6): 7-12, 2016.
Article
en Zh
| WPRIM
| ID: wpr-488072
Biblioteca responsable:
WPRO
ABSTRACT
Recently,increasing cancer researches focus on antibody-drug conjugates(ADCs) which can improve the anti-tumor potency with less adverse effect while benefiting patients in the future. However,safety evaluation of ADCs is a big challenge because of complex components as well as in experience in preclinical studies. In this review,the authors reviewed the mode of action,hazard risks,and toxicity observed in preclinical/clinical studies of ADCs,summarized the preclinical studies of Adcetris(brentuximab vedotin)and Kadcyla(ado-trastuzumab emtansine),and suggested a better strategy of ADCs in preclinical safety evaluation.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Pharmacology and Toxicology
Año:
2016
Tipo del documento:
Article