Progress in alternative testing strategies for human embryonic stem cell-based drug toxicity / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
; (6): 173-177, 2016.
Article
en Zh
| WPRIM
| ID: wpr-488126
Biblioteca responsable:
WPRO
ABSTRACT
Traditional drug development and pre-clinical tests are based on animals and involve large numbers of animals,costs and long periods. Meanwhile,inter-species differences are difficult to overcome. Human embryonic stem cells (hESCs),which can self-renew and directly differentiate to types of cells,have become a new tool for toxicity alternative testing. hESC-Based alternative testing models,such as the reproductive toxicity test system,neuro development toxicity test system and metabolic model,can be used to predict target organ toxicity and toxic mechanisms of chemicals, analyze metabolic pathways and to search for potential toxicity biomarkers, when combined with omics such techiniques as metabonomics , proteomics and genomics. Therefore, hESC-based alternative testing models have extensive application to toxicology.
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1
Índice:
WPRIM
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Pharmacology and Toxicology
Año:
2016
Tipo del documento:
Article