Signaling pathways of epithelial-mesenchymal transition in colon cancer / 国际肿瘤学杂志

ABSTRACT

Epithelial-mesenchymal transition (EMT) plays a critical role in the carcinogenesis of colon cancer,and promotes the tumor invasion and metastasis.Studies have shown several signals are involved including transforming growth factor-β (TGF-β),Wnt/β-catein,Notch,nuclear factor-κB (NF-κB) and PI3K/Akt signal pathway.It is important to elucidate EMT-related signal pathway thereby providing new insights into possible therapeutic interventions of colon cancer.